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School of Medicine Established in 1930, Duke University School of Medicine is the youngest of the nation's top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,500 faculty physicians and researchers, more than 1,300 students, and more than 6,000 staff, the Duke University School of Medicine along with the Duke University School of Nursing, Duke University Health System and the Private Diagnostic Clinic (PDC) comprise Duke Health. a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.
Work involves identifying novel classes of T cell-reactive antigens across different human cancers, to rationally design universal anti-cancer vaccines and more effective immunotherapies. Specifically, leverage optimized methods for Ribo-seq analyses and a novel bioinformatical pipeline to identify the effect of cells tress in the translatome of tumor and non-mutated cells. This work could exert a profound effect in the field by first, defining a novel class of tumor antigens, induced by tumor microenvironmental conditions, which could be shared by multiple cancers and is likely absent in healthy cells. Second, these studies could provide a rationale a new generation of vaccines to prevent carcinogenesis or tumor recurrence. Third, this work has the potential to provide a platform to quickly identify tumor-reactive TCRs that could target tumors of multiple origins in patients with common HLA alleles.
PhD in biological Sciences required
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Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.
Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.
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