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School of Medicine Established in 1930, Duke University School of Medicine is the youngest of the nation's top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,500 faculty physicians and researchers, more than 1,300 students, and more than 6,000 staff, the Duke University School of Medicine along with the Duke University School of Nursing, Duke University Health System and the Private Diagnostic Clinic (PDC) comprise Duke Health. a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.
Work involves developing immunotherapies against human cancer, using a dual approach: On the one hand, this position will develop tumor cell-penetrating antibodies that targets intracellular on co-drivers, based on the use of dimeric IgA and chimeric immunoglobulins co-targeting intracellular antigens and PIGR. On the other hand, it will optimize non-viral integration procedures for expressing novel chimeric constructs that re-direct T cells against tumor antigens, based on CRISPR-mediated targeting of Er stress pathways and chimeric receptors connected to a gamma delta TCR.
The position requires extensive expertise in both Immuno-Oncology and Molecular Biology.
Ph.D. or equivalent doctorate (e.g. Sc.D., M.D., D.V.M.)
5 + years of postdoctoral experience conducting scientific research. Multiple publicastions and notable signficant contributions to scientific research.
Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.
Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.
Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.
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