School of Medicine Established in 1930, Duke University School of Medicine is the youngest of the nation's top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,500 faculty physicians and researchers, more than 1,300 students, and more than 6,000 staff, the Duke University School of Medicine along with the Duke University School of Nursing, Duke University Health System and the Private Diagnostic Clinic (PDC) comprise Duke Health. a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.

The Patel Lab recently relocated to Duke and joined the Department of Neurosurgery, Preston Robert Tisch Brain Tumor Center and the Center for Advanced Genomic Technologies to continue groundbreaking work on single cell genomics in brain tumors. The lab is seeking a postdoctoral fellow to conduct cutting single cell multiomics research to study brain tumor heterogeneity and evolution during therapy. Particular focus of the lab includes single cell analyses of patient samples, development and study of complex patient specific tumor models to understand minimal residual disease and tumor evolution during therapy, development of single cell profiling methods, and use of functional genomics to understand tumor dynamics.

Specific projects currently include:

Single cell profiling of patient derived tumor slice culture models to study minimal residual disease after standard of care therapy and targeted therapy

Development of a joint single cell RNA/CUT&Tag multiomic profiling method

Pooled CRIPSR screening targeting epigenetic modifiers in in vivo patient derived xenograft models of glioblastoma heterogeneity

Application of novel therapeutic strategies for targeting glioblastoma in preclinical models, including the development of immunotherapy based treatment paradigms

Job functions include:

Plan and conduct experiments using cutting edge methods and technical instruments (including single cell methods, next generation sequencing)

Review scientific literature to keep abreast of new findings and to obtain information regarding experimental methods to aid in the design of new procedures and methods.

Confer with principal investigator to determine specific experiments to be included in the research and to discuss the interpretation of results.

Generate and maintain a variety of patient specific model systems including 3D cultures, tumor slice cultures and patient derived xenografts

Supervise and train students, technicians, graduate students in laboratory techniques and procedures.

Write scientific manuscripts for publication in high quality, peer reviewed journals.

Perform other related duties incidental to the work described herein.

The above statements describe the general nature and level of work being performed by individuals assigned to this classification. This is not intended to be an exhaustive list of all responsibilities and duties required of personnel in this classification.

Education/Training: Work requires a PhD in a related field.

Minimum Qualifications
Education

See job description for education requirements.

Experience

See job description for requirements.

Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.

Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.

Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.