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Post-Doctoral Scholar

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University of Kentucky

Location: Lexington, Kentucky
Category: Admin-Other Administrative Positions
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Job Description

Posting Details
Posting Details

Job Title	Post-Doctoral Scholar
Requisition Number	DU11167
Department Name	7H030:SANDERS-BROWN CTR ON AGING
Work Location	Lexington, KY
Salary Range	56,484.00
Type of Position	Temporary
Position Time Status	Full-Time
Required Education	must hold PhD
Required Related Experience	Knowledge of experimental design Statistical and quantitative analysis skills Self-motivated and highly dedicated Effective organizational and prioritization skills Strong writing skills evident in published work and efficient grantsmanship skills Effective oral, written, and interpersonal communication skills Ability to work both independently as well as collaboratively in a multidisciplinary environment.
Required License/Registration/Certification	n/a
Physical Requirements	May require long periods or sitting and/or standing; may require lifting up to 25lbs
Shift	Primarily days but may require occasional work on evenings or weekends
Job Summary	The Maj-Linda Selenica’s laboratory in the Sanders-Brown Center of Aging, Departments of Biochemistry at University of Kentucky is currently looking for highly skilled and motivated molecular and cell biologists to be the drivers of our efforts to unravel mechanisms contributing to the TDP-43 pathology of limbic-predominant age-related TDP-43 encephalopathy (LATE) and other Alzheimer’s Disease Related Dementias (ADRD). Core areas of focus will be understanding the role of citrullination and other PTMs in the TDP-43 protein structure, biology, and pathology into both in vitro (induced pluripotent stem cell models) and in vivo systems (mouse models) to understand the clinical outcomes of TDP-43 pathogenesis in LATE and ADRD. In particular, our lab concentrates on identifying the role of citrullination in recombinant TDP-43 liquid-liquid phase separation and aggregation kinetics (ThT, TEM, FRAP) and dissecting the molecular, cellular, and tissue-level mechanisms by which this PTM and the associated enzymes (e.g., PADs) modulate disease risk, with a major focus on cell-specific role on the regional milieu and disease pathology. The candidate will join a multidisciplinary and highly collaborative research team that includes geneticists, immunologists, biostatisticians, neuroscientists, and neuropathologist at the Sanders-Brown Center on Aging as one of the leading centers in the country for ADRD and LATE research and clinical interventions. The Sanders-Brown Center on Aging and Selenica Laboratory strongly believes that diversity and inclusion is a driver for excellence. We share a common devotion to delivering exceptional patient care. Yet we’re as diverse as the city we call home- culturally, ethically, in outlook and lifestyle. When you join us, you become a part of Sanders- Brown Center on Aging unrivaled record of achievement, education, and advancement as we revolutionize healthcare delivery together. We work hard to recruit and retain the best people, and to create a welcoming, nurturing work environment where you have the opportunity and support to develop professionally. We share the belief that all employees, regardless of job title or expertise, have an impact on quality patient care. Explore more about this opportunity and how you can help us write a new chapter in our story!
Skills / Knowledge / Abilities	Strong research experience in human iPSC technology and targeted genome editing in vitro (preferred) – or – Strong research experience in high-throughput technologies single-cell transcriptomics, epigenomics, lipidomics and/or proteomics (preferred) – or – Strong research experience in functional genomics (e.g., siRNA, shRNA, CRISPR/Cas9) screens (preferred) Strong research experience in establish, modify, and optimize techniques related to the areas of neuroscience, inflammation, and disordered proteins. Expertise in high throughput imaging techniques including but not limited to confocal, electron microscopy, FRAP, 2P imaging. Strong research experience in small animal surgery, AAV methods etc., is highly preferred. Knowledge of experimental design Statistical and quantitative analysis skills Self-motivated and highly dedicated Effective organizational and prioritization skills Strong writing skills evident in published work and efficient grantsmanship skills Effective oral, written, and interpersonal communication skills Ability to work both independently as well as collaboratively in a multidisciplinary environment.
Does this position have supervisory responsibilities?	No
Preferred Education/Experience	Ph.D. in Biology, Neuroscience, or related field with deep expertise in molecular and cellular biology techniques Strong research experience in human iPSC technology and targeted genome editing in vitro (preferred) – or – Strong research experience in high-throughput technologies single-cell transcriptomics, epigenomics, lipidomics and/or proteomics (preferred) – or – Strong research experience in functional genomics (e.g., siRNA, shRNA, CRISPR/Cas9) screens (preferred) Strong research experience in establish, modify, and optimize techniques related to the areas of neuroscience, inflammation, and disordered proteins. Expertise in high throughput imaging techniques including but not limited to confocal, electron microscopy, FRAP, 2P imaging. Strong research experience in small animal surgery, AAV methods etc., is highly preferred.
Deadline to Apply	09/21/2023
University Community of Inclusion	The University of Kentucky is committed to a diverse and inclusive workforce by ensuring all our students, faculty, and staff work in an environment of openness and acceptance. We strive to foster a community where people of all backgrounds, identities, and perspectives can feel secure and welcome. We also value the well-being of each of our employees and are dedicated to creating a healthy place to work, learn and live. In the interest of maintaining a safe and healthy environment for our students, employees, patients and visitors the University of Kentucky is a Tobacco & Drug Free campus. As an Equal Opportunity Employer, we strongly encourage veterans, individuals with disabilities, women, and all minorities to consider our employment opportunities. Any candidate offered a position may be required to pass pre-employment screenings as mandated by University of Kentucky Human Resources. These screenings may include a national background check and/or drug screen.