The Targeted Protein Degradation (TPD) Proteomics Core within the Fischer Lab at Dana-Farber Cancer Institute serves as a resource for the Cancer Biology Department, aiding investigators in answering key research questions using mass spectrometry-based proteomics. We employ quantitative chemoproteomic and interactomic approaches to identify drug targets and are continuing to expand our repertoire to meet the needs of our core users.

The TPD Core seeks a highly motivated individual to join the team as a Research Scientist, who will employ mass spectrometry-based technologies to assess the cellular proteome in response to external stimuli. This individual will be an important member of our core team and will work with technicians, scientists, postdocs and students on a variety of different research projects focused on targeted protein degradation as a novel therapeutic modality.  https://fischerlab.dana-farber.org/

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world-renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong.  As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff.  Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

• Responsible for cell culture and performing drug treatments
• Performs mass spectrometry sample preparation and data analysis
• Analyzes experimental data and interprets results to generate reports and presentations
• Communicates with and explains results to collaborators
• Maintains detailed notebook of all work-related activities
• Maintains highly organized sample and data tracking and reporting workflows
• Operation and maintenance of standard lab equipment
• Operation and maintenance of HPLC and LCMS instruments
• Maintains and orders laboratory supplies
• Communicates with purchasing and may be responsible for negotiating with vendors

• Ph.D in biochemistry, chemistry, biology or related field highly preferred
• Experience with mammalian cell culture and proteomics sample preparation is required
• Experience operating Thermo and Bruker mass spectrometers is preferred
• Proficiency in mass spectrometry data analysis and quantitative methods
• Proficiency in statistical and computational methods and R programming is preferred
• Knowledge of proteomics data analysis software, including Proteome Discoverer
• Must have excellent communication skills
• Must have close attention to detail and consistent work habits
• Ability to work within a team environment
• Must have good time management

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

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