POSITION TITLE: Postdoctoral Associate - Regenerative Medicine

ABOUT US
Calibr was founded on the principle that the creation of new medicines can be accelerated by pairing world-class biomedical research with state-of-the-art drug discovery and development capabilities. Calibr, a division of Scripps Research, is a first-of-its-kind, nonprofit translational research institute dedicated to creating the next generation of medicines. Scripps Research is ranked the most influential institution in the world for its impact on innovation. Our educational and training programs mold talented and committed students and postdocs into leading edge scientists. Leveraging the unique scientific environment of Scripps Research, impacting translational sciences, Calibr has created a portfolio of drug candidates, and is shaping a new paradigm for advancing nonprofit biomedical research to impact patients while re-investing in further innovative research. We expand basic knowledge in the biosciences and use these fundamental advancements to develop profound innovations that improve wellbeing. Functioning much like a small biotechnology company but within a non-profit setting with a decade of experience, Calibr's drug development portfolio spans a broad range of human diseases, including cancer, autoimmunity and inflammatory diseases, metabolic and cardiovascular diseases, infectious and neglected diseases, as well as age-related and degenerative diseases. If you have a passion for making a difference, this could be your opportunity to join our transformative team. Calibr supplements the discovery process with the required disciplines for drug development which include chemical library screening, medicinal chemistry, in-vivo model optimization, formulation development, pharmacokinetic and toxicologic expertise, and early clinical development.

POSITION SUMMARY

We are seeking talented Cellular Biologist to join a dynamic, interdisciplinary team of scientists focused on early-stage translational research in regenerative medicine. Postdoctoral researcher will work as part of a team to develop small molecule therapeutic candidates that promote regenerative tissue repair. The researcher will perform cellular cell-based experiments to evaluate the activity of synthesized lead analogs designed to optimize the potency, pharmacokinetics, safety, and in vivo efficacy of potential drug candidates. Depending on the stage of the project, the motivated biologist will join Calibr colleagues and collaborate in the drug development process learning the design and execution aspects of early drug development with hands-on experience as desired.

RESPONSIBILITIES AND DUTIES

• Development and execution of miniaturized cell-based assays to evaluate the effects of lead compounds.
• Perform cellular biological experiments to characterize the response of identified lead compounds, including Western blotting, RT-qPCR, RNA-sequencing, and immunofluorescence.
• Perform target identification experiments to identify the cellular interactors of phenotypic screening hits.
• Processing and evaluation of complex transcriptomic and proteomic data.
• Regular communication of results to the drug development team in the form of presentations and meetings.
• Review literature and patents to retrieve key scientific information needed for research projects.
• Details of established essential functions for this position will be addressed/discussed during the interview process.

REQUIREMENTS

• Ph.D. in Biological Sciences or related field
• Strong skills and a proven track record in mammalian cell culture, especially of that of complex biological systems like organoids and tissue explants
• Excellent proficiency in cellular biological techniques including Western blotting, immunoprecipitation, immunofluorescence, high content imaging.
• Excellent proficiency in molecular biological techniques including DNA purification, molecular cloning, protein purification
• Ability to perform and design rodent experiments is preferred
• Profound literature search skills, the ability to design and improve biological methodology
• Highly motivated, creative, and able to maintain excellent documentation of their work
• Able to collaborate proficiently and communicate effectively with colleagues and management team
• Excellent verbal, written, interpersonal and collaborative communication skills

PHYSICAL REQUIREMENTS:

May include: Stationary position for an extended period of time, traverse campus/facility as needed, operate machinery such as computer, phone, copy machine; exposure to cold or hot temperatures.

COMPENSATION

Postdoctoral Associates will be hired following the National Institute of Health and California's exempt salary guidelines, which provide for a starting range of $68,000 - $70,000. Consideration will be given to experience that exceeds the listed requirements.

The above statements describe the level of work performed and expected in general terms. The statements are not intended to list all the responsibilities, duties and/or skills required of employees so classified, and the content herein is subject to change due to the business needs of Scripps Research, with or without notice. Furthermore, nothing in this job description shall be interpreted to be in conflict with or to eliminate or modify in any way the employment-at-will status of Scripps Research staff.

EEO Statement

The Scripps Research Institute is an Equal Opportunity Employer. We promote diversity of thought, culture and background in the fields of science. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status. Underrepresented individuals are encouraged to apply.