Job Description

Job Title: Investigator, Chemistry
About Us
Calibr, a division of Scripps Research, is a first-of-its-kind, nonprofit translational research institute dedicated to creating the next generation of medicines. Calibr was founded on the principle that the creation of new medicines can be accelerated by pairing world-class biomedical research with state-of-the-art drug discovery and development capabilities. Scripps Research is ranked one of the most influential institution in the world for its impact on innovation. Our educational and training programs mold talented and committed students and postdocs into leading edge scientists. Leveraging the unique scientific environment of Scripps Research, impacting translational sciences, Calibr has created a portfolio of drug candidates, and is shaping a new paradigm for advancing nonprofit biomedical research to impact patients while re-investing in further innovative research. We expand basic knowledge in the biosciences and use these fundamental advancements to develop profound innovations that improve wellbeing. Calibr's drug development portfolio spans a broad range of human diseases, including cancer, autoimmunity and inflammatory diseases, metabolic and cardiovascular diseases, infectious and neglected diseases, as well as age-related and degenerative diseases. If you have a passion for making a difference, this could be your opportunity to join our transformative team.
Job Summary
Part of a dynamic, interdisciplinary team of scientists focused on early stage translational research. Works with project team to develop new therapeutic approaches to unmet medical needs. Work is published in high-impact, peer-reviewed journals and optimized for partnerships with various for-profit and non-profit organizations.
Responsibilities and Duties
  • Uses unique scientific expertise to contribute to key research projects in alignment with Calibr's mission and goals
  • Performs highly specialized research on drug discovery based on medchem and SAR while demonstrating successful scientific expertise across focused areas
  • Design new analogs for improvement of activity, ADME and in vivo PK and efficacy based on medchem and SAR and previous drug discovery experience.
  • Uses profound knowledge of the field and current literature to maintain a pipeline for successful pre-clinical candidates
  • Works with research team to identify and develop new relevant and viable research projects
  • Supervises one or more colleagues
  • Authors research reports, generates scientific presentations and manages research timelines
  • Details of established essential functions for this position will be addressed/discussed during the interview process.
Decision Making
Independently designs, executes, interprets and reports results of work. Additionally, oversees consistency and accuracy of results and documentation. Expected to make decisions and solve the majority of problems that arise with minimal management input. Escalates issues and risks that significantly affect timelines.
Will communicate with colleagues, CRO personnel, and management teams to execute projects effectively.
Scope and Complexity
Investigator is independently responsible for assigned strategic and day-to-day research activities. Works collaboratively with teams in coordination of group goals. Works on extremely complex problems and requires the ability to adapt quickly and evaluate intangible variables. Exercises judgement in developing methods, techniques and criteria for obtaining results.
Supervision of Others
Manages one or more colleagues. Participates in recruitment, selection and training of team members. May provide training and mentorship to other lower level scientific staff.
Position Requirements
  • Candidates must have Ph.D. in a Chemistry/medicinal chemistry with 3-5 years of drug discovery based on medchem and SAR
  • Prior experience managing scientific staff and/or postdoctoral associates
  • Strong laboratory skills and a proven track record in area of specified science
  • Demonstration of highly successful project execution across disease areas using in-house and/or CRO resources leading to preclinical candidates for further clinical development
  • Highly motivated, creative, and devoted to project goals
  • Impeccable attention to detail, and excellent ability to perform hands on experiments, research, design, and organize project designs and maintain detailed documentation
  • Able to contribute in a meaningful way to scientific discourse
  • Prior involvement in IND-enabling activities are highly preferred
  • Highly motivated, creative, and able to maintain excellent documentation of their work including writing grant applications and third-party partnership plans
  • Able to collaborate proficiently and communicate effectively with colleagues, project management and senior leadership
  • Experience in structure-based drug design including docking is a plus.


The expected hiring range for this position is $105,000 to $120,000, commensurate with experience. Consideration will be given to experience that exceeds the listed requirements.


May include: Stationary position for an extended period of time, traverse campus/facility as needed, operate machinery such as computer, phone, copy machine; exposure to cold or hot temperatures.


  • Eligibility for retirement plans with employer contribution.
  • Full suite of Health and Welfare plans including three medical plan options (including an HSA available option), dental, vision, life insurance, disability, EAP and more.
  • Access to Flexible Spending Accounts (Medical/Dependent Care).
  • Competitive vacation and sick leave policies.
  • Free, on-site Counseling Center which provides confidential counseling services to benefits-eligible employees and their family members.
  • Free, on-site parking.
The above statements describe the level of work performed and expected in general terms. The statements are not intended to list all the responsibilities, duties and/or skills required of employees so classified, and the content herein is subject to change due to the business needs of Scripps Research, with or without notice. Furthermore, nothing in this job description shall be interpreted to be in conflict with or to eliminate or modify in any way the employment-at-will status of Scripps Research staff.
EEO Statement:
The Scripps Research Institute is an Equal Opportunity Employer. We promote diversity of thought, culture and background in the fields of science. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status. Underrepresented individuals are encouraged to apply.

The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.


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