POSTDOCTORAL ASSOCIATE, Medicinal Chemistry
Job Description
DescriptionCalibr, a division of Scripps Research, is a first-of-its-kind, nonprofit translational research institute dedicated to creating the next generation of medicines. Calibr was founded on the principle that the creation of new medicines can be accelerated by pairing world-class biomedical research with state-of-the-art drug discovery and development capabilities. Scripps Research is ranked one of the most influential institutions in the world for its impact on innovation. Our educational and training programs mold talented and committed students and postdocs into leading edge scientists. Leveraging the unique scientific environment of Scripps Research, impacting translational sciences, Calibr has created a portfolio of drug candidates, and is shaping a new paradigm for advancing nonprofit biomedical research to impact patients while re-investing in further innovative research. We expand basic knowledge in the biosciences and use these fundamental advancements to develop profound innovations that improve wellbeing. Calibr's drug development portfolio spans a broad range of human diseases, including cancer, autoimmunity and inflammatory diseases, metabolic and cardiovascular diseases, infectious and neglected diseases, as well as age-related and degenerative diseases. If you have a passion for making a difference, this could be your opportunity to join our transformative team.
We are seeking talented synthetic chemists with a passion for medicinal chemistry and drug discovery to join a dynamic, interdisciplinary team of scientists focused on translational research. Postdoctoral researchers in the medicinal chemistry group will work as part of a team of scientists to design, synthesize, and characterize small molecules that represent new therapeutic approaches to address unmet medical needs. The researcher will play a core role in optimizing the potency, pharmacokinetics, safety, and in vivo efficacy of potential drug candidates. The work environment will utilize industry standard cutting-edge equipment/software and foster comprehensive opportunities to learn core concepts of drug development to progress early leads all the way to the clinic. Work will lead to publications in high-impact peer-reviewed journals, patents, and/or collaborative development opportunities with pharmaceutical companies.
- Maintain sustained productivity, engaging in proactive constant communication with supervisors and team members
- Design new compounds utilizing medicinal chemistry principals, literature research, and structure-based drug design
- Synthesize and characterize target molecules using varieties of techniques such as organic synthesis, column chromatography, LCMS, and NMR spectroscopy
- Conduct structure-activity relationship (SAR) studies to perform lead optimization and generate candidates with drug-like properties for progression to clinical studies
- Review literature and patents to retrieve key scientific information needed for research projects
- Details of other established essential functions for this position will be addressed/discussed during the interview process.
- Ph.D. in chemistry
- Strong skills and a proven track record in synthetic organic chemistry, compound purification, and structural characterization
- Highly motivated, creative, and able to maintain excellent documentation of their work
- Profound literature search skills, ability to design and improve synthetic routes to support SAR studies.
- Ability to meet deadlines in the delivery of final compounds (at milligram or gram scales) and comprehensive research summaries
- Able to collaborate proficiently and communicate effectively with colleagues and management team
- Excellent verbal, written, interpersonal and collaborative communication skills
- Prior exposure to structure-based drug design and/or other medicinal chemistry paradigms a plus
COMPENSATION:
Postdoctoral Associates will be hired following the National Institute of Health and California's exempt salary guidelines, which provide for a starting range of $68,000 - $70,000. Consideration will be given to experience that exceeds the listed requirements.
PHYSICAL REQUIREMENTS:
May include: Stationary position for an extended period of time, traverse campus/facility as needed, operate machinery such as computer, phone, copy machine; exposure to cold or hot temperatures.
COMPREHENSIVE BENEFITS INCLUDE:
- Eligibility for retirement plans with employer contribution.
- Full suite of Health and Welfare plans including three medical plan options (including an HSA available option), dental, vision, life insurance, disability, EAP and more.
- Access to Flexible Spending Accounts (Medical/Dependent Care).
- Competitive vacation and sick leave policies.
- Free, on-site Counseling Center which provides confidential counseling services to benefits-eligible employees and their family members.
- Free, on-site parking.
The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
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