At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.

Neurocrine Biosciences is a neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson's disease, endometriosis* and uterine fibroids*, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. *in collaboration with AbbVie

About the Role:

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• Develops new biochemical and cell-based assays

• Performs routine assays to support lead identification and optimization

• Performs MOA studies using flow cytometry, ELISA/MSD, western blotting, transient transfections, and other techniques as needed

• Responsible for data analysis and reporting

• Tracks and documents assay performance

• Continually provides recommendations to improve on process efficiency and research quality

• Other duties as assigned

• BS/BA degree in scientific field and 2+ years of in vitro pharmacology experience; Preferred experience includes: primary cell culture, especially CNS, and related assay development, liquid handling automation and LIMS systems, GPCRs and related in vitro assays OR

• MS/MA degree in scientific field and some relevant industry experience OR

• PhD in biology or related field preferred

• some experience with cell culture and cell-based in vitro assays, development and optimization of in vitro biological assays is required Preferred experience includes: primary cell culture, especially CNS, and related assay development, liquid handling automation and LIMS systems, GPCRs and related in vitro assays

• Ability to independently design and perform standard and novel immune cell assays to validate immunological targets, and create detailed protocols and related documents

• Hands-on experience with isolation and manipulation of human or mouse blood and tissue derived primary cells such as macrophages, splenocytes, PBMCs, microglia, neurons, and astrocytes

• Hands-on experience with a broad array of in vitro techniques including but not limited to tissue culture, transfections, flow cytometry, MSD, ELISA, western blot, and qPCR

• Working knowledge of automated liquid handlers and LIMS systems

• Capable of independent lab work within a collaborative environment, with minimal guidance to explore, develop and validate novel methods and models for neurological and inflammatory disorders

• Expertise in cell sorting (FACS), flow cytometry analysis, cell phenotyping analysis, functional immune assays, and signaling pathways in immune, glial, and neuronal cells

• Recognizes fundamental anomalies in data points and identifies issues in experiments / processes

• Begins to understand how to think outside of the technical process and consider the impact decisions will have on the broader scientific goals

• Strong knowledge of one scientific discipline

• Good knowledge of scientific principles, methods and techniques

• Good knowledge and demonstrated ability working with a variety of laboratory equipment/tools

• Ability to work as part of a team

• Strong computer skills

• Good communications, problem-solving, analytical thinking skills

• Detail oriented

• Ability to meet deadlines

• Good project management skills

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Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.

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