Key Duties and Responsibilities:

• Provide in silico genetic toxicity assessments to project teams and the Vertex Impurities Safety Team (VIST)
• Work with Vertex scientists to identify toxico-informatics challenges, then plan and implement data solutions including workflows, databases and dashboards to address data analysis, modeling, and automation needs
• Identify, optimize and conduct cutting-edge in silico safety assessment of Vertex therapeutic targets and molecules to identify potential development challenges
• Develop and execute a transcriptomics data modelling strategy to predict specific organ toxicities
• Work with internal and external partners to guide the development, deployment, and continuous improvement of current and new quantitative systems toxicology approaches (improving prediction and translation of drug safety risks)
• Interact with strategic partners to design and execute transcriptomic studies and other potential computational analyses to meet specific project needs
• Communicate unambiguous critical and significant data to various bodies including project teams and Vertex leadership as required
• Develop external collaborations within the academic and industrial sectors to enhance Vertex's discovery toxicology capabilities

Knowledge and Skills:

• Experience with scripting (Python or R/Bioconductor)
• Ability to design, develop, and deploy databases (e.g. Oracle, MySQL, etc.) and computational pipelines (e.g., Snakemake, Docker, etc.)
• Strong and demonstrable interpersonal skills with an ability to develop solid, long-term relationships and to influence others
• Proven computational / scientific acumen with the ability to creatively seek resolutions to complex issues
• Strong problem solver who is highly organized with the ability to thrive and lead in a matrixed work environment with rapidly changing priorities
• Experience of working on cross-disciplinary project and delivery teams

Other Requirements

• Experience conducting gene expression analysis
• Experience utilizing predictive genetic toxicology tools and models

Education and Experience:

• Bachelor's degree, Masters degree or PhD - computational focus
• PhD and 0-3 years of experience or,
• Masters degree and 3 years of experience or,
• Bachelors degree and 6 years of experience

In this Hybrid-Eligible role, you can choose to be designated as:

#LI-Hybrid

#LI-BS1

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com.