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Duke University

Job Description

Full job description

School of Medicine

Established in 1930, Duke University School of Medicine is the youngest of the nation's top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,600 faculty physicians and researchers, nearly 2,000 students, and more than 6,200 staff, the Duke University School of Medicine along with the Duke University School of Nursing, and Duke University Health System comprise Duke Health, a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Health Integrated Practice, Duke Primary Care, Duke Home Care and Hospice, Duke Health and Wellness, and multiple affiliations.

The primary duties for this position are to develop and test a high-throughput cell-free assay for measuring the DNA-binding specificity of dCas9.


Job duties include:

  • Using existing data from the Gersbach and Crawford labs to develop DNA libraries containing guide RNAs with different properties (e.g. different specificities, different effects on gene expression, or different phenotypic effects)
  • Developing and refining experimental protocols for testing dCas9 in complex with select gRNAs for their DNA-binding specificity and sensitivity
  • Pre-processing and analyzing the results obtained using the new assay
  • Preparing the results for presentation in manuscripts and grant applications.


The candidate should have, at minimum, Masters or Ph.D. in a relevant field and at a minimum, experience with DNA-binding


Minimum Qualifications



See job description for education requirements.


 See job description for requirements.


Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.


Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.


Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.

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