School of Medicine

Established in 1930, Duke University School of Medicine is the youngest of the nation's top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,600 faculty physicians and researchers, nearly 2,000 students, and more than 6,200 staff, the Duke University School of Medicine along with the Duke University School of Nursing, and Duke University Health System comprise Duke Health, a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Health Integrated Practice, Duke Primary Care, Duke Home Care and Hospice, Duke Health and Wellness, and multiple affiliations.

The primary duties for this position are to develop and test a high-throughput cell-free assay for measuring the DNA-binding specificity of dCas9.

Job duties include:

• Using existing data from the Gersbach and Crawford labs to develop DNA libraries containing guide RNAs with different properties (e.g. different specificities, different effects on gene expression, or different phenotypic effects)

• Developing and refining experimental protocols for testing dCas9 in complex with select gRNAs for their DNA-binding specificity and sensitivity

• Pre-processing and analyzing the results obtained using the new assay

• Preparing the results for presentation in manuscripts and grant applications.

The candidate should have, at minimum, Masters or Ph.D. in a relevant field and at a minimum, experience with DNA-binding

Minimum Qualifications

Education

See job description for education requirements.

 Experience

 See job description for requirements.

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Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.