Job Description

Posting Number

Internal Recruitment

Working Title

Anticipated Hiring Range

Work Schedule

Job Location

Department

About the Department

• Mass spectrometry: small molecule identification and structural analysis, targeted and untargeted metabolomics, proteomics, lipidomics, MS imaging.
• NMR spectroscopy: small molecule and macromolecular solution structures, protein-ligand interactions, protein dynamics.
• X-ray crystallography: small molecule and macromolecular crystal structure determination.
• Education, training and outreach: METRIC offers training to new users, enhances graduate and undergraduate education through providing formal instruction, organizing educational materials, short courses and workshops to support users, maintaining protocols for routine sample handling, and hosting regular forums for users to interact and share new methods.

Essential Job Duties

• Serve as the point of contact for client inquiries in the area of small molecule analysis by targeted and untargeted metabolomics, including lipidomics.
• Provide expert advice on experimental design, including selection of sample preparation techniques and analytical methods, to ensure methodological rigor and feasibility.
• Collaborate with other staff members to develop and optimize metabolomics experimental protocols.
• Stay abreast of the latest advances in analytical methods and techniques to integrate into research projects.

• Perform liquid, liquid-liquid, or SPE extraction, derivatization, and other pre-analytical steps to ensure sample integrity and suitability for downstream analysis.
• Operate and maintain LC-MS metabolomics instrumentation (e.g. Thermo TSQ Altis Triple Quadrupole, Exploris 240, Exploris 480, ID-X).
• Develop and implement standard operating procedures (SOPs) for sample handling and preparation to ensure consistency across studies.

• Perform metabolomics studies and report the results (analyte peak area or concentrations) using relevant software such as Skyline, MS-Dial, and Compound Discoverer.
• Use appropriate statistical and bioinformatics tools to extract meaningful biological insights.
• Perform pathway analysis using specialized software and databases, as needed.
• Interpret complex datasets and collaborate with researchers to contextualize findings within the scope of the project.
• Prepare detailed reports and visualizations of data for internal review, publication in scientific journals, and inclusion in grant applications.

• Maintain accurate and up-to-date laboratory records, including experimental protocols, data logs, and inventory of samples and reagents.
• Coordinate with the operations manager to ensure adequate supplies; ensure continuity of operations by coordinating maintenance of major instrumentation and associated ancillary equipment.
• Assist in the training and supervision of staff and students in metabolomics techniques and best practices.
• Contribute to the preparation of manuscripts, grant applications, and progress reports for funding agencies.
• Ensure compliance with institutional and regulatory requirements related to biosafety, data management, and ethical standards.

Other Responsibilities

Minimum Education and Experience

• Ph.D. in a relevant field, with at least five years of experience in metabolomics research methods and/or post-degree professional work experience with a demonstrated record of research achievement.

• Relevant Master’s degree, plus at least 8 years of exceptional relevant professional work experience and a record of research achievements.

• In rare instances, an individual with comparable professional experience but less than a master’s degree will be considered, on an exception basis. May require terminal degree and licensure.

Other Required Qualifications

• Significant experience in untargeted and targeted metabolomics, advanced separations, tandem MS, absolute quantification, IROA, credentialing, bioinformatics, and metabolome databases.
• Demonstrated ability to develop workflows and standard operating procedures (SOPs).
• Must possess exceptional communication skills, including written and verbal, be highly organized and detail-oriented.
• Must be able to work independently, use initiative, prioritize tasks, and anticipate potential pressure points in workflows.
• Ability to develop and maintain productive collaborative work relationships with all clients by listening, understanding and responding to apparent and underlying needs and continually seeking to provide the highest quality service to all.

Preferred Qualifications

• Prefer experience with lipidomics and/or mass spectrometry-based imaging.
• Prefer experience with integrating data from multiple-omics based approaches.

Required License(s) or Certification(s)

Valid NC Driver's License required

Commercial Driver's License required

Job Open Date

Anticipated Close Date

Special Instructions to Applicants

Position Number

Position Type

Full Time Equivalent (FTE) (1.0 = 40 hours/week)

Appointment

Mandatory Designation - Adverse Weather

Mandatory Designation - Emergency Events

Department ID

AA/EEO

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