At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine, and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visitneurocrine.com, and follow the company on LinkedIn, X (Formerly Twitter) and Facebook. (*in collaboration with AbbVie)

About the Role:

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• Design, execute, and analyze SPR and BLI experiments to determine antibody affinity (KD), kinetics, pH dependent binding, competition experiments, dual-target engagement, epitope binning against various antigens, including recombinant proteins, Nanodisc, VLP. Experience with cells a plus

• Independently develop, optimize and troubleshoot protocols to evaluate monospecific and bispecific antibodies, scFv, Fabs, peptides and small molecules

• Apply extensive QC parameters to data to identify and troubleshoot issues

• Extensive knowledge of Biacore Insight and Octet Analysis software for data analysis

• Regular maintenance of SPR and BLI instrumentation

• Prepare high-quality data reports and presentations for project meetings

• Collaborate with scientists in a highly matrixed environment across multiple therapeutic areas and function teams

• Stay current with the latest advancements in SPR, BLI, and antibody, peptide and small molecule characterization techniques

• Must be highly organized with strong attention to details, and an eye on critical decision-making data generation

• BS/BA degree in scientific field and 2+ years of in vitro pharmacology experience; Preferred experience includes: SPR and BLI for characterizing protein-protein interactions and binding kinetics, related assay development and troubleshooting OR

• MS/MA degree in scientific field and some relevant industry experience OR

• PhD in biology or related field preferred and some experience with antibody drug discovery, antibody characterizations, assay development and optimization and related troubleshooting, experience with SPR and BLI is required. Preferred experience includes: SPR and BLI for characterizing antibody-protein interactions with strong assay development and troubleshooting skills

• Recognizes fundamental anomalies in data points and identifies issues in experiments / processes

• Begins to understand how to think outside of the technical process and consider the impact decisions will have on the broader scientific goals

• Strong knowledge of one scientific discipline

• Good knowledge of scientific principles, methods and techniques

• Good knowledge and demonstrated ability working with a variety of laboratory equipment/tools

• Ability to work as part of a team

• Strong computer skills

• Good communications, problem-solving, analytical thinking skills

• Detail oriented

• Ability to meet deadlines

• Good project management skills

• Demonstrated experience with measuring antibody binding kinetics, pH dependent, competition binding, dual engagement binding studies using Biacore SPR methods

• Experience with obtaining epitope binning and binding/competition binding studies using Octet BLI methods

• Ability to QC and troubleshoot experiments.

• Collaborative and highly motivated

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Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.

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